Venugopal Balakrishnan
Name
Venugopal Balakrishnan
Current Position
Associate Professor
venugopal@usm.my
Office Telephone
+604-6534840
Qualifications
B. Appl. Sc., Universiti Sains Malaysia, 2001
M.Sc., Universiti Sains Malaysia, 2004
PhD, Universiti Sains Malaysia, 2009
Affiliations
Malaysian Biosafety and Biosecurity Association
Persatuan Genetik Malaysia
Research Interests
Molecular Oncology, Epigenetics, Genotyping, Microbial Antibiotic Resistance, Biosafety and Biosecurity.
Research Overview 1
HPV E7oncogne regulation in cell-cycle
The regulation of cell-cycle from G0 toG1 phase is control by CTCF/YB-1 complex which sits at c-myc promoter by regulating the gene transcription. The CTCF/YB-1 complex is disrupted by HPV E7 oncogene, thus allow the expression of c-myc to be exponential and the cell-cycle progression become uncontrollable, thus the cell enters tumor phase. The research is to further look into the cascading effects of c-myc gene exponential expression towards malignancy of cervical cancer.
Research Overview 2
Expression of Bst DNA polymerase
The Bst DNA polymerase is an enzyme used for isothermal amplification assays. We have manage to synthetically engineered Bst DNA polymerase and the enzyme is being used to develop isothermal amplification assay using Helicase Dependent Amplification platform.
Selected Publications
1. Suppan M, Shamsuddin S, Ismail A, Balakrishnan V (2015) PCR-based Gene Synthesis, Cloning, Expression, Purification and Characterization of Bst DNA Polymerase in E. coli Cells. Curr Synthetic Sys Biol 3:126. doi:10.4172/2332-0737.1000126
2. Md. Sohrab Hossain, Nik Norulaini Nik Ab Rahman, Venugopal Balakrishnan, Abbas F.M. Alkarkhi, Zainul Ahmad Rajion, Mohd Omar Ab Kadir. 2015. Optimizing supercritical carbon dioxide in the inactivation of bacteria in clinical solid waste by using response surface methodology. Waste Management. 231-237
3. Md. Sohrab Hossain, Venugopal Balakrishnan, Nik Norulaini Nik Ab Rahman, Md. Zaidul Islam Sarker, Mohd Omar Ab Kadir. 2015. Mathematical modeling of Enterococcus faecalis, Escherichia coli, and Bacillus sphaericus inactivation in infectious clinical solid waste by using steam autoclaving and supercritical fluid carbon dioxide sterilization. Chem Eng J. 267 (2015), 221-234.
4. Venugopal Balakrishnan, Hajarul Azwana Ab Wahab, Khairunisak Abdul Razak, Sahaharum Shamsuddin. 2013. In Vitro Evaluation of Cytotoxicity of Colloidal Amorphous Silica Nanoparticles Designed for Drug Delivery on Human Cell Lines. Journal of Nanomaterials. DOI: 10.1155/2013/729306
5. Puvanesuaran, V.R., Ibrahim, N., Noordin, R., Balakrishnan, V. 2013. Genotyping of Toxoplasma gondii isolates from wild boars in Peninsular Malaysia. PLoS One. (DOI: 10.1371/journal.pone.0061730)
6. Puvanesuaran, V.R., Noordin, R., Balakrishnan, V. 2013. Isolation and genotyping of Toxoplasma gondii from free-range ducks in Malaysia. Avian Dis. doi: 10.1637/10304-071212-ResNote.1.
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