Tye Gee Jun
Name
Tye Gee Jun
Current Position
Senior Lecturer
geejun@usm.my
Office Telephone
+604-6534804
Qualifications
BSc. (Biotechnology), Universiti Putra Malaysia, Selangor
Ph.D (Immunology), King's College London, UK
Affiliations
Research Interests
Immunology, Vaccine, Adjuvant, Mammalian Protein Expression
Research Overview 1
Development of Peptide Vaccination regimens for improve T-cell responses
Peptide vaccines are key immunotherapeutic that could lead to safer and more targeted stimulation of the immune system. However, due to its size, immunogenecity is likely to be poorer compared to subunit vaccine or full protein vaccine. A key area that is required to enable efficient stimulation of the immune system when peptides are use as targets is adjuvants. Adjuvant is derived from the Latin word adiuvare, that means to help. Here, adjuvant is defined as an addition that would accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific antigens.
Selected Publications
1. Tye, Gee Jun et al. "The Combined Molecular Adjuvant CASAC Enhances The CD8+ T Cell Response To A Tumor-Associated Self-Antigen In Aged, Immunosenescent Mice". Immunity & Ageing 12.1 (2015): n. pag. Web.
2. Tye, Gee Jun et al. "Vaccines For TB: Lessons From The Past Translating Into Future Potentials". Journal of Immunology Research 2015 (2015): 1-9.
3. Lee, Shin Yong et al. "DNA Fluorescence Shift Sensor: A Rapid Method For The Detection Of DNA Hybridization Using Silver Nanoclusters". Journal of Colloid and Interface Science 433 (2014): 183-188.
4. Ingram, Wendy et al. "Human CD80/IL2 Lentivirus Transduced Acute Myeloid Leukaemia Cells Enhance Cytolytic Activity In Vitro In Spite Of An Increase In Regulatory CD4+ T Cells In A Subset Of Cultures". Cancer Immunology, Immunotherapy 58.10 (2009): 1679-1690. Web.
Author Address
