Nurulhasanah Othman

Infografik NHO 2022



Nurulhasanah Binti Othman

Current Position



Office Telephone



BSc (Hons), Universiti Kebangsaan Malaysia, 2002

MSc, Universiti Sains Malaysia, 2007

PhD, Universiti Sains Malaysia, 2012


Human Proteome Organization (HUPO)

Malaysian Society of Parasitology and Tropical Medicine (MSTPM)

Research Interests

Proteomics, mass spectrometry, parasitology, infectious diseases and molecular biology

Research Overview 1

Proteomics Research

Proteomics is defined as a study of the entire proteome of living organisms from various taxa. With the aid of state-of-art technologies using mass spectrometry, protein identification and quantification are currently emerging regardless by gel-based a or non-gel based (shotgun proteomics) workflows in many research laboratories of developed and developing countries. This would provide valuable information for proteomics scientists mainly in the biomedical field to discover new biological marker in to order to help them develop a better diagnostic tool for diseases, develop new drug and vaccine as well as to understand the mechanism of diseases. In her lab, the LC-MALDI-TOF/TOF is utilized for the protein identification and quantitation either using gel-based or non-gel based approaches mainly to elucidate the proteome of a protozoan parasite namely Entamoeba histolytica. This would then contribute to better understanding of pathogenesis of the parasite and some of the identified protein molecules maybe can be used further for new drug and vaccine developments to combat amoebiasis. Furthermore, this technology also will be used also in cancer research and other related research at USM.

Selected Publications

  1. Othman, N., Zainuddin, N.S., Mohamed, Z., Yahya, M.M., Leow, V.M.and Noordin, R. Protein expression in sera of patients with amoebic liver abscess (ALA) : potential use of  haptoglobin as a surrogate disease marker. Tropical Biomedicine. 2013. 30(2): 257-266.
  2. Rahmah N. and Nurulhasanah, O. Proteomic technologies- A powerful tool for proteomics scientists. Malaysian Journal of Medical Sciences.  2013. 20(2): 1-2.
  3. Nurulhasanah, O., Zeehaida, M., Maya M.Y., Leow, V. M., Lim B.H., Rahmah N.Entamoeba histolytica antigenic protein detected in pus aspirates from patients with amoebic liver abscess. 2013. Experimental Parasitology 134: 504-510.
  4. N.S.Zainuddin, N.Othman,J. Muhi, A.A.A Sani and R. Noordin.  MESA Protein Identified in the Serum of Plasmodium falciparum-Infected Patients.  2015. American Journal Tropical Medicine and Hygiene doi: 10.4269/ajtmh.15-0333.
  5. Jorim A.U., S. H. Kwan, M.N. Ismail, B. H. Lim, R. Noordin and N. Othman.  . Proteome analysis of excretory secretory proteins of Entamoeba histolytica   HM1:IMSS via  LC–ESI–MS/MS and LC–MALDI–TOF/TOF. 2016. Clin Proteom  13:33.DOI  10.1186/s12014-016-9135- 8

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