Nurulhasanah Othman
Name
Nurulhasanah Binti Othman
Current Position
Lecturer
nurulhasanah@usm.my
Office Telephone
+604-6534877
Qualifications
BSc (Hons), Universiti Kebangsaan Malaysia, 2002
MSc, Universiti Sains Malaysia, 2007
PhD, Universiti Sains Malaysia, 2012
Affiliations
Human Proteome Organization (HUPO)
Malaysian Society of Parasitology and Tropical Medicine (MSTPM)
Research Interests
Proteomics, mass spectrometry, parasitology, infectious diseases and molecular biology
Research Overview 1
Proteomics Research
Proteomics is defined as a study of the entire proteome of living organisms from various taxa. With the aid of state-of-art technologies using mass spectrometry, protein identification and quantification are currently emerging regardless by gel-based a or non-gel based (shotgun proteomics) workflows in many research laboratories of developed and developing countries. This would provide valuable information for proteomics scientists mainly in the biomedical field to discover new biological marker in to order to help them develop a better diagnostic tool for diseases, develop new drug and vaccine as well as to understand the mechanism of diseases. In her lab, the LC-MALDI-TOF/TOF is utilized for the protein identification and quantitation either using gel-based or non-gel based approaches mainly to elucidate the proteome of a protozoan parasite namely Entamoeba histolytica. This would then contribute to better understanding of pathogenesis of the parasite and some of the identified protein molecules maybe can be used further for new drug and vaccine developments to combat amoebiasis. Furthermore, this technology also will be used also in cancer research and other related research at USM.
Selected Publications
- Othman, N., Zainuddin, N.S., Mohamed, Z., Yahya, M.M., Leow, V.M.and Noordin, R. Protein expression in sera of patients with amoebic liver abscess (ALA) : potential use of haptoglobin as a surrogate disease marker. Tropical Biomedicine. 2013. 30(2): 257-266.
- Rahmah N. and Nurulhasanah, O. Proteomic technologies- A powerful tool for proteomics scientists. Malaysian Journal of Medical Sciences. 2013. 20(2): 1-2.
- Nurulhasanah, O., Zeehaida, M., Maya M.Y., Leow, V. M., Lim B.H., Rahmah N.Entamoeba histolytica antigenic protein detected in pus aspirates from patients with amoebic liver abscess. 2013. Experimental Parasitology 134: 504-510.
- N.S.Zainuddin, N.Othman,J. Muhi, A.A.A Sani and R. Noordin. MESA Protein Identified in the Serum of Plasmodium falciparum-Infected Patients. 2015. American Journal Tropical Medicine and Hygiene doi: 10.4269/ajtmh.15-0333.
- Jorim A.U., S. H. Kwan, M.N. Ismail, B. H. Lim, R. Noordin and N. Othman. . Proteome analysis of excretory secretory proteins of Entamoeba histolytica HM1:IMSS via LC–ESI–MS/MS and LC–MALDI–TOF/TOF. 2016. Clin Proteom 13:33.DOI 10.1186/s12014-016-9135- 8
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