Khairul Mohd Fadzli Mustaffa
Name
Khairul Mohd Fadzli Mustaffa
Current Position
Lecturer
khairulmf@usm.my
Office Telephone
+609-7672435
Qualifications
PhD in Tropical Medicine, University of Liverpool, 2012
MSc in Pharmacology, Universiti Sains Malaysia, 2008
BSc in Biotechnology, Universiti Putra Malaysia, 2002
Affiliations
The International Society on Aptamers (INSOAP)
Malaysian Scientific Association (MSA)
Malaysian Malaria Network
Research Interests
Molecular therapeutics,
Theranostics,
Research Overview 1
Molecular therapeutics
The current focus is understanding molecular and cellular interaction that contributed to severe malaria development, with an emphasis on discovery of novel compounds (natural and synthetic compounds) and potential new biomarkers for therapeutic interventions.
Research Overview 2
Theranostics
Theranostics merging therapeutic and diagnostics to advance personalized medicine especially Point-of-Care (POC) of patients. At the moment, the lab developing RNA and DNA aptamer against a diverse set of target
biomarkers as an alternative of monoclonal antibody for infectious diseases diagnostics and therapy.
Selected Publications
1. Aptamer Technology: Adjunct Therapy for Malaria. Nik Kamarudin NAA, Mohammed NA, Mustaffa KMF. Biomedicines. 2017 Jan 4;5(1).
2. From the Natural Compound (+)-Epigallocatechin Gallate to a Simplified Synthetic Analogue as a Cytoadherence Inhibitor for Plasmodium falciparum.Gemma, Sandra; Brogi Simone; Patil, Pradeep; Brindisi, Margherita; Butini, Stefania; Novellino, Ettore; Brown, Alan; Higgins, Matthew; Mustafa, Khairul; Szestak, Tadge; Craig, Alister; Campiani, Giuseppe. The Royal Society of Chemistry. 2014 Dec 16;4(9):4769.
3. Cytoadherence and severe malaria. Craig AG, Khairul MF, Patil PR. Malays J Med Sci. 2012 Apr;19(2):5-18.
4. Automated counting for Plasmodium falciparum cytoadherence experiments. 2. Paton D, Faragher B, Mustaffa KM, Szestak T, Barret SD, Craig AG. Malar. J. 2011 Apr 16:10:91.
5. Roxithromycin reverses chloroquine and mefloquine resistance in Plasmodium falciparum in vitro. T. H. Min, M. F. M. Khairul, J. H. Low, C. H. Che Nasriyyah, A. Noor A’shikin, M. N. Norazmi, M. Ravichandran and S. S. Raju. Exp Parasitol. 2007 Apr;115(4):387-92.
6. Fluoxetine potentiates chloroquine and mefloquine effect on multidrug-resistant Plasmodium falciparum in vitro. Khairul MF, Min TH, Low JH, Nasriyyah CH, A'shikin AN, Norazmi MN, Ravichandran M, Raju SS. Jpn J Infect Dis. 2006 Oct;59(5):329-31.
Author Links
