Sasidharan Sreenivasan
Name
Sasidharan Sreenivasan
Current Position
Associate Professor
Office Telephone
+604-6534820
Qualifications
BSc (Hons), Universiti Sains Malaysia
MSc, Universiti Sains Malaysia
PhD, Universiti Sains Malaysia
Affiliations
International Society for Infectious Diseases
Research Interests
Natural products, apoptosis, miRNA, oxidative stress, antimicrobial, animal model research
Research Overview 1
Anti-cancer therapeutic potential of natural products
The recent discovery of microRNAs has added an exciting new layer of research interest in the fields of medical research in general including cancer. His work mainly on MicroRNA–mediated regulation of apoptosis in cancer cells by various natural products. Besides that, he also studies the molecular mechanism of cell cytotoxicity of natural products. These fundamental findings may provide clues to further our understanding of the mechanisms and roles of microRNAs as key regulators of apoptotic programmed cell death induced by natural products in cancer cells and their prospect in the future medical application, especially in the development of green natural products based anticancer medicine.
Research Overview 2
Pharmacological activities of standardized plants secondary metabolites
His research also concentrate on evaluation of plants secondary metabolites in biological and pharmacological activities (Plant extraction, standardization of plant extract, antitoxoplasma activity, antimicrobial activity, antioxidant activity, hepatoprotective activity, prevention of biofilm formation by C. albicans, wound healing activity, anticancer activity, antidiarrheal activity and toxicology studies) and understanding the mechanism of action of the standardized extract or bioactive compound on various pathogenic microbes such as Candida albicans, Helicobacter pylori, Pseudomonas aeruginosa and Aspergillus fumigatus.
Research Overview 3
Animal Research
His research also concentrates on using the animal model to prove the efficacy natural product which showed good activity at in vitro level. He uses the animal model in acute and chronic oral toxicity study, wound healing activity, infected wound healing activity, hepatoprotective study and in vivo antimicrobial study.
Selected Publications
1. Vijayarathna, S., Oon, C.E., Chen, Y., Kanwar, J.R. & Sasidharan, S. 2017, "Polyalthia longifolia Methanolic Leaf Extracts (PLME) induce apoptosis, cell cycle arrest and mitochondrial potential depolarization by possibly modulating the redox status in hela cells", Biomedicine and Pharmacotherapy, vol. 89, pp. 499-514.
2. Kavitha, N., Ein Oon, C., Chen, Y., Kanwar, J.R. & Sasidharan, S. 2017, "Phaleria macrocarpa (Boerl.) fruit induce G0/G1 and G2/M cell cycle arrest and apoptosis through mitochondria-mediated pathway in MDA-MB-231 human breast cancer cell", Journal of ethnopharmacology, vol. 201, pp. 42-55.
3. Dawar, S., Singh, N., Kanwar, R.K., Kennedy, R.L., Veedu, R.N., Zhou, S.-., Krishnakumar, S., Hazra, S., Sasidharan, S., Duan, W. & Kanwar, J.R. 2013, "Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers", Drug discovery today, vol. 18, no. 23-24, pp. 1292-1300.
4. Gurudevan, S., Kanwar, R.K., Veedu, R.N., Sasidharan, S., Kennedy, R.L., Walder, K., Prasad, N. & Kanwar, J.R. 2013, "Targeted multimodal liposomes for nano-delivery and imaging: An avenger for drug resistance and cancer", Current Gene Therapy, vol. 13, no. 5, pp. 322-334.
5. Jothy, S.L., Aziz, A., Chen, Y. & Sasidharan, S. 2012, "Antioxidant activity and hepatoprotective potential of polyalthia longifolia and cassia spectabilis leaves against paracetamol-induced liver injury", Evidence-based Complementary and Alternative Medicine, vol. 2012.
6. Jothy, S.L., Chen, Y., Kanwar, J.R. & Sasidharan, S. 2013, "Evaluation of the genotoxic potential against h 2 o 2 -radical-mediated DNA damage and acute oral toxicity of standardized extract of polyalthia longifolia leaf", Evidence-based Complementary and Alternative Medicine, vol. 2013.
7. Jothy, S.L., Chen, Y., Vijayarathna, S., Kanwar, J.R. & Sasidharan, S. 2015, "MicroRNAs: Association with radioresistant and potential uses of natural remedies as green gene therapeutic approaches", Current Gene Therapy, vol. 15, no. 1, pp. 15-20.
8. Jothy, S.L., Yeng, C. & Sasidharan, S. 2013, "Chromatographic and spectral fingerprinting of Polyalthia longifolia, a source of phytochemicals", BioResources, vol. 8, no. 4, pp. 5102-5119.
9. Jothy, S.L., Zakaria, Z., Chen, Y., Lau, Y.L., Latha, L.Y. & Sasidharan, S. 2011, "Acute oral toxicity of methanolic seed extract of Cassia fistula in mice", Molecules, vol. 16, no. 6, pp. 5268-5282.
10. Jothy, S.L., Zakaria, Z., Chen, Y., Lau, Y.L., Latha, L.Y., Shin, L.N. & Sasidharan, S. 2011, "Bioassay-directed isolation of active compounds with antiyeast activity from a cassia fistula seed extract", Molecules, vol. 16, no. 9, pp. 7583-7592.
11. Kamilla, L., Mansor, S.M., Ramanathan, S. & Sasidharan, S. 2009, "Effects of clitoria ternatea leaf extract on growth and morphogenesis of aspergillus niger", Microscopy and Microanalysis, vol. 15, no. 4, pp. 366-372.
12. Kanwar, J.R., Mahidhara, G., Roy, K., Sasidharan, S., Krishnakumar, S., Prasad, N., Sehgal, R. & Kanwar, R.K. 2015, "Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc", Nanomedicine, vol. 10, no. 1, pp. 35-55.
13. Latha, L.Y., Darah, I., Kassim, M.J.N.M. & Sasidharan, S. 2010, "Antibacterial activity and morphological changes of Pseudomonas aeruginosa cells after exposure to vernonia cinerea extract", Ultrastructural pathology, vol. 34, no. 4, pp. 219-225.
14. Sangetha, S., Zuraini, Z., Sasidharan, S. & Suryani, S. 2008, "Fungicidal effect and oral acute toxicity of Cassia spectabilis leaf extract", Japanese Journal of Medical Mycology, vol. 49, no. 4, pp. 299-304.
15. Sasidharan, S., Darah, I. & Noordin, M.K.M.J. 2010, "In vitro antimicrobial activity against Pseudomonas aeruginosa and acute oral toxicity of marine algae Gracilaria changii", New Biotechnology, vol. 27, no. 4, pp. 390-396.
16. Sasidharan, S., Logeswaran, S. & Latha, L.Y. 2012, "Wound healing activity of Elaeis guineensis leaf extract ointment", International Journal of Molecular Sciences, vol. 13, no. 1, pp. 336-347.
17. Sasidharan, S. & Uyub, A.M. 2009, "Antibody response to Helicobacter pylori excretory antigen and the cross reaction study", Journal of Immunoassay and Immunochemistry, vol. 30, no. 1, pp. 70-81.
18. Sasidharan, S. & Uyub, A.M. 2009, "Prevalence of Helicobacter pylori infection among asymptomatic healthy blood donors in Northern Peninsular Malaysia", Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 103, no. 4, pp. 395-398.
19. Sasidharan, S., Uyub, A.M. & Azlan, A.A. 2008, "Further evidence of ethnic and gender differences for Helicobacter pylori infection among endoscoped patients", Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 102, no. 12, pp. 1226-1232.
20. Sasidharan, S., Zuraini, Z., Yoga Latha, L., Sangetha, S. & Suryani, S. 2008, "Antimicrobial activities of Psophocarpus tetragonolobus (L.) DC extracts", Foodborne Pathogens and Disease, vol. 5, no. 3, pp. 303-309.
21. Uthaya Kumar, U.S., Chen, Y., Kanwar, J.R. & Sasidharan, S. 2016, "Redox control of antioxidant and antihepatotoxic activities of cassia surattensis seed extract against paracetamol intoxication in mice: In vitro and in vivo studies of herbal green antioxidant", Oxidative Medicine and Cellular Longevity, vol. 2016.
22. Vijayarathna, S., Oon, C.E., Jothy, S.L., Chen, Y., Kanwar, J.R. & Sasidharan, S. 2014, "MicroRNA pathways: An emerging role in identification of therapeutic strategies", Current Gene Therapy, vol. 14, no. 2, pp. 112-120.
23. Yoga Latha, L., Darah, I., Jain, K. & Sasidharan, S. 2011, "Effects of Vernonia cinerea Less methanol extract on growth and morphogenesis of Candida albicans", European review for medical and pharmacological sciences, vol. 15, no. 5, pp. 543-549.
24. Yuet Ping, K., Darah, I., Chen, Y., Sreeramanan, S. & Sasidharan, S. 2013, "Acute and subchronic toxicity study of euphorbia hirta L. methanol extract in rats", BioMed Research International, vol. 2013.
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